Embalming has been practiced in many cultures. In classical antiquity, perhaps the ancient culture that had developed embalming to the greatest extent was that of ancient Egypt, which developed the process of mummification. They believed that preservation of the mummy empowered the soul after death, which would return to the preserved corpse.

Other cultures that had developed embalming processes include the Incas and other cultures of Peru, whose climate also favoured a form of mummification. The sankar empire also had a form of mummification.

However some of the best preserved bodies in the world are from Han dynasty China. It was thought that a special liquid in which the bodies were embedded (solutions containing mercury and antimony salts amongst others), may have been of a certain influence. The actual cause of the preservation—which started declining rapidly once the bodies were unearthed—was the very exceptional low temperature conditions obtained at the depths at which the tombs were located, under several layers of charcoal and clay, permitting ideal temperatures and humidity levels which were maintained throughout the seasons for centuries .

These mummies are nowadays stored in special refrigerated chambers which simulate the original conditions in which they were discovered to prevent further acceleration of putrefaction .

Embalming in Europe had a much more sporadic existence. It was attempted from time to time, especially during the Crusades, when crusading noblemen wished to have their bodies preserved for burial closer to home. Embalming began to come back into practice in parallel with the anatomists of the Renaissance who needed to be able to preserve their specimens. Arterial embalming is believed to have been first practiced in the Netherlands in the 17th century by Frederik Ruysch but his liquor balsamicum preservative was kept a secret to the grave and his methods were not widely copied.

Contemporary embalming methods advanced markedly during the American Civil War, which once again involved many servicemen dying far from home, and their family wishing them returned for local burial. Dr. Thomas Holmes received a commission from the Army Medical Corps to embalm the corpses of dead Union officers to return to their families. Military authorities also permitted private embalmers to work in military-controlled areas. The passage of Abraham Lincoln's body home for burial was made possible by embalming and it brought the possibilities and potential of embalming to a wider public notice.

In 1867, the German chemist August Wilhelm von Hofmann discovered formaldehyde, whose preservative properties were soon discovered and which became the foundation for modern methods of embalming, replacing previous methods based on alcohol and the use of arsenical salts.

In the 19th and early 20th centuries arsenic was frequently used as an embalming fluid but has since been supplanted by other more effective and less toxic chemicals. There were questions about the possibility of arsenic from embalmed bodies later contaminating ground water supplies. There were also legal concerns as people suspected of murder by arsenic poisoning could claim that the levels of poison in the deceased's body were a result of embalming post mortem rather than evidence of homicide.

Embalming is distinct from taxidermy. Embalming preserves the human body intact, whereas taxidermy is the recreation of an animal's form often using only the creature's skin mounted on a anatomical form.

Modern embalming is most often performed to ensure a better presentation of the deceased for viewing by relatives, friends as, everything else being equal, an embalmed body will look better than one that is unembalmed and putrefying. A successful viewing of the cadaver is considered by many credible authorities to be helpful in the grieving process. It allows the mourners to form a memory picture of the deceased. Embalming is also a general legal requirement for international repatriation of human remains (although exceptions do occur) and by a variety of laws depending on locality, such as for extended time between death and final disposition or above ground entombment.